FK506 immunosuppression for submandibular salivary gland allotransplantation in rabbit
Almansoori Akram Abdo, Khentii Namuun, 주경원, 김봉준, 김성민, 이종호,
소속 상세정보
( Almansoori Akram Abdo ) - Seoul National University School of Dentistry Department of Oral and Maxillofacial Surgery
( Khentii Namuun ) - Seoul National University School of Dentistry Department of Oral and Maxillofacial Surgery
주경원 ( Ju Kyung-Won ) - Seoul National University Dental Hospital Clinical Translational Research Center for Dental Science
김봉준 ( Kim Bong-Jun ) - Seoul National University Dental Hospital Clinical Translational Research Center for Dental Science
김성민 ( Kim Soung-Min ) - Seoul National University School of Dentistry Department of Oral and Maxillofacial Surgery
이종호 ( Lee Jong-Ho ) - Seoul National University School of Dentistry Department of Oral and Maxillofacial Surgery
Abstract
Objectives: We compared the outcomes of two different doses of FK506 (tacrolimus) for immunosuppression in submandibular salivary gland (SMG) allotransplantation.
Materials and Methods: Three SMG allotransplantation groups were established (n=6 per group) as follows: allograft rejection control (Allo-Ctrl), low dose (0.08 mg/kg) of FK506 (FK506-L), and high dose (0.16 mg/kg) of FK506 (FK506-H). Allograft survival and rejection were assessed by clinical observation, interleukin-2 levels as determined by enzyme-linked immunosorbent assay, blood sampling for complete blood count (CBC), and histological evaluation.
Results: Body weight and anorexia were higher in the FK506-H group but without a significant difference compared with the FK506-L population. CBC revealed a non-significantly reduced number of changes in the FK506-L group. Four glands in the FK506-H group and two glands in the FK506-L group were viable and functioning post-transplantation.
Conclusion: The survival rate of allotransplanted glands was higher in conjunction with the high dose of 0.16 mg/kg of FK506, with no major differ-ence in the side-effect profile when compared with the low dose of 0.08 mg/kg short-term outcomes.
키워드
Submandibular salivary gland; Allotransplantation; Immunosuppression; FK506; Tacrolimus
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